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par1 antagonist, fr171113  (Tocris)


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    Tocris par1 antagonist, fr171113
    A. SC35, SC38, and SC40 were incubated with CatG, LF, CatGinh., DMSO, CatG with LF, CatG with LF and CatG inhibitor (CatGinh.), CatG with LF and DMSO, or CatG with CatGinh. for 24h at 37°C. Cell surface expression of A . <t>PAR1</t> or B. MHC I was determined by flow cytometry. All values were normalized to the isotype control. Eight independent experiments were performed ( n = 8) and summarized in a bar diagram. SC35, SC38, and SC40 were treated with different proteases (CatG, CatS, NE, PAR3, and thrombin) for 24h at 37°C and levels of PAR1 C. or MHC I D. were analyzed by flow cytometry. Nine independent experiments were performed ( n = 9) and values were normalized to the isotype control.
    Par1 Antagonist, Fr171113, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/par1+antagonist%2C+fr171113/sch79797/pmc05342690-107-8-13
    Average 90 stars, based on 1 article reviews
    par1 antagonist, fr171113 - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells"

    Article Title: Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells

    Journal: Oncotarget

    doi: 10.18632/oncotarget.12980

    A. SC35, SC38, and SC40 were incubated with CatG, LF, CatGinh., DMSO, CatG with LF, CatG with LF and CatG inhibitor (CatGinh.), CatG with LF and DMSO, or CatG with CatGinh. for 24h at 37°C. Cell surface expression of A . PAR1 or B. MHC I was determined by flow cytometry. All values were normalized to the isotype control. Eight independent experiments were performed ( n = 8) and summarized in a bar diagram. SC35, SC38, and SC40 were treated with different proteases (CatG, CatS, NE, PAR3, and thrombin) for 24h at 37°C and levels of PAR1 C. or MHC I D. were analyzed by flow cytometry. Nine independent experiments were performed ( n = 9) and values were normalized to the isotype control.
    Figure Legend Snippet: A. SC35, SC38, and SC40 were incubated with CatG, LF, CatGinh., DMSO, CatG with LF, CatG with LF and CatG inhibitor (CatGinh.), CatG with LF and DMSO, or CatG with CatGinh. for 24h at 37°C. Cell surface expression of A . PAR1 or B. MHC I was determined by flow cytometry. All values were normalized to the isotype control. Eight independent experiments were performed ( n = 8) and summarized in a bar diagram. SC35, SC38, and SC40 were treated with different proteases (CatG, CatS, NE, PAR3, and thrombin) for 24h at 37°C and levels of PAR1 C. or MHC I D. were analyzed by flow cytometry. Nine independent experiments were performed ( n = 9) and values were normalized to the isotype control.

    Techniques Used: Incubation, Expressing, Flow Cytometry

    Related Articles

    Incubation:

    Article Title: Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells
    Article Snippet: To determine CatG specificity, CatG was preincubated with CatG inhibitor I (100 μM, Calbiochem, Schwalbach, Germany), Suc-Val-Pro-Phe P (OPh) 2 (Suc-VPF, 100 μM; Jozef Oleksyszyn, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw, Poland), or the cysteine protease inhibitor E64 (100 μM, Enzo Life Sciences). .. In a separate experiment, PBMCs were incubated with PAR1 antagonist, FR171113 (10 mM, Tocris) for 6 h at 37°C. ..



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    A. SC35, SC38, and SC40 were incubated with CatG, LF, CatGinh., DMSO, CatG with LF, CatG with LF and CatG inhibitor (CatGinh.), CatG with LF and DMSO, or CatG with CatGinh. for 24h at 37°C. Cell surface expression of A . <t>PAR1</t> or B. MHC I was determined by flow cytometry. All values were normalized to the isotype control. Eight independent experiments were performed ( n = 8) and summarized in a bar diagram. SC35, SC38, and SC40 were treated with different proteases (CatG, CatS, NE, PAR3, and thrombin) for 24h at 37°C and levels of PAR1 C. or MHC I D. were analyzed by flow cytometry. Nine independent experiments were performed ( n = 9) and values were normalized to the isotype control.
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    A. SC35, SC38, and SC40 were incubated with CatG, LF, CatGinh., DMSO, CatG with LF, CatG with LF and CatG inhibitor (CatGinh.), CatG with LF and DMSO, or CatG with CatGinh. for 24h at 37°C. Cell surface expression of A . <t>PAR1</t> or B. MHC I was determined by flow cytometry. All values were normalized to the isotype control. Eight independent experiments were performed ( n = 8) and summarized in a bar diagram. SC35, SC38, and SC40 were treated with different proteases (CatG, CatS, NE, PAR3, and thrombin) for 24h at 37°C and levels of PAR1 C. or MHC I D. were analyzed by flow cytometry. Nine independent experiments were performed ( n = 9) and values were normalized to the isotype control.
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    Image Search Results


    A. SC35, SC38, and SC40 were incubated with CatG, LF, CatGinh., DMSO, CatG with LF, CatG with LF and CatG inhibitor (CatGinh.), CatG with LF and DMSO, or CatG with CatGinh. for 24h at 37°C. Cell surface expression of A . PAR1 or B. MHC I was determined by flow cytometry. All values were normalized to the isotype control. Eight independent experiments were performed ( n = 8) and summarized in a bar diagram. SC35, SC38, and SC40 were treated with different proteases (CatG, CatS, NE, PAR3, and thrombin) for 24h at 37°C and levels of PAR1 C. or MHC I D. were analyzed by flow cytometry. Nine independent experiments were performed ( n = 9) and values were normalized to the isotype control.

    Journal: Oncotarget

    Article Title: Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells

    doi: 10.18632/oncotarget.12980

    Figure Lengend Snippet: A. SC35, SC38, and SC40 were incubated with CatG, LF, CatGinh., DMSO, CatG with LF, CatG with LF and CatG inhibitor (CatGinh.), CatG with LF and DMSO, or CatG with CatGinh. for 24h at 37°C. Cell surface expression of A . PAR1 or B. MHC I was determined by flow cytometry. All values were normalized to the isotype control. Eight independent experiments were performed ( n = 8) and summarized in a bar diagram. SC35, SC38, and SC40 were treated with different proteases (CatG, CatS, NE, PAR3, and thrombin) for 24h at 37°C and levels of PAR1 C. or MHC I D. were analyzed by flow cytometry. Nine independent experiments were performed ( n = 9) and values were normalized to the isotype control.

    Article Snippet: In a separate experiment, PBMCs were incubated with PAR1 antagonist, FR171113 (10 mM, Tocris) for 6 h at 37°C.

    Techniques: Incubation, Expressing, Flow Cytometry